[Importance of daily serum progesterone measurement in ovulation induction]. / Znacajnost dnevnog doziranja progesterona u serumu u toku stimulacije ovulacije.

ABSTRACT

It is known that the rise of serum progesterone concentration frequently precedes the rise of serum luteinizing hormone in spontaneous menstrual cycles and during induction of ovulation. The aim of this study was to evaluate the role of single serum progesterone measurement in the prediction of spontaneous serum luteinizing hormone rise in patients with ovulation induction. The study concerned 97 infertile women. The induction of ovulation was performed according to individual endocrine profile of a patient. In 59 (61%) patients spontaneous increase of luteinizing hormone was not recorded and in 31 (32%) patients this increase was evident. In 7 (7%) high serum luteinizing hormone concentration was measured at the time of use of human chorionic gonadotropin. The correlation between serum progesterone level and serum luteinizing hormone concentration in patients with spontaneous serum luteinizing hormone rise was statistically significant (r=0.79; p<0.01). The double daily serum progesterone rise is an important method for prediction of serum luteinizing hormone rise (x2=24.08; p<0.001). After the use this method the pregnancy rate was 29 percent in our study group.