Synthesis and cytotoxicity evaluation of 22,23-oxygenated stigmastane derivatives.
Bioorg Med Chem
; 16(3): 1460-73, 2008 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-17983753
ABSTRACT
Starting from (22E)-3alpha,5alpha-cyclo-6beta-methoxystigmast-22-ene eighteen derivatives of (22S,23S)-22,23-oxidostigmastane, (22R,23R)-22,23-oxidostigmastane, and (22R,23R)-22,23-dihydroxystigmastane were synthesized and screened for cytotoxicity in human hepatoma Hep G2 cells and human breast carcinoma MCF-7 cells using MTT assay. Four compounds of this series exhibited high cytotoxicity in both cells; three compounds were selectively toxic in MCF-7 cells, one compound was toxic in Hep G2 cells, rather than in MCF-7 cells; four compounds at low concentrations increased MTT test values over the control.
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Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Colestenonas
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article