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Association of polymorphisms in the dopamine D4 receptor gene and the activity-impulsivity endophenotype in dogs.
Hejjas, K; Vas, J; Topal, J; Szantai, E; Ronai, Z; Szekely, A; Kubinyi, E; Horvath, Z; Sasvari-Szekely, M; Miklosi, A.
Afiliação
  • Hejjas K; Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Puskin u. 9, Budapest, H-1088, Hungary.
Anim Genet ; 38(6): 629-33, 2007 Dec.
Article em En | MEDLINE | ID: mdl-17986156
A variable number of tandem repeats (VNTR) polymorphism in exon 3 of the human dopamine D4 receptor gene (DRD4) has been associated with attention deficit hyperactivity disorder (ADHD). Rodents possess no analogous repeat sequence, whereas a similar tandem repeat polymorphism of the DRD4 gene was identified in dogs, horses and chimpanzees. Here, we present a genetic association study of the DRD4 VNTR and the activity-impulsivity dimension of the recently validated dog-ADHD Rating Scale. To avoid false positives arising from population stratification, a single breed of dogs (German shepherd) was studied. Two DRD4 alleles (referred to as 2 and 3a) were detected in this breed, and genotype frequencies were in Hardy-Weinberg equilibrium. For modelling distinct environmental conditions, 'pet' and 'police' German shepherds were characterized. Police German shepherds possessing at least one 3a allele showed significantly higher scores in the activity-impulsivity dimension of the dog-ADHD Rating Scale than dogs without this allele (P = 0.0180). This difference was not significant in pet German shepherds. To the best of our knowledge, this is the first report of an association between a candidate gene and a behaviour trait in dogs, and it reinforces the functional role of DRD4 exon 3 polymorphism.
Assuntos
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Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Comportamento Animal / Cães / Receptores de Dopamina D4 / Comportamento Impulsivo Idioma: En Ano de publicação: 2007 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Comportamento Animal / Cães / Receptores de Dopamina D4 / Comportamento Impulsivo Idioma: En Ano de publicação: 2007 Tipo de documento: Article