Effects of exercise training on endothelial progenitor cells in patients with chronic heart failure.
J Card Fail
; 13(9): 701-8, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-17996817
ABSTRACT
BACKGROUND:
The enhancement of circulating endothelial progenitor cells (EPCs) obtained by exercise training can be beneficial to patients with cardiac disease. Changes in the levels and differentiation of CD34(pos)/KDR(pos) EPCs, as well as the plasma concentration of vascular endothelial growth factor (VEGF) and stromal cell-derived factor (SDF)-1 EPC-mobilizing cytokines, were evaluated in patients with chronic heart failure after 8 weeks of supervised aerobic training (SAT) and 8 weeks of subsequent discontinued SAT (DSAT). METHODS ANDRESULTS:
The levels of circulating EPC and EPC differentiation potential of 22 patients who underwent SAT were studied by fluorescence-activated cell sorter analysis and colony forming-unit assay, respectively. The plasma levels of VEGF and SDF-1 were measured by enzyme-linked immunosorbent assay. In response to SAT, the levels of both EPC and VEGF/SDF-1 markedly increased (P < .001 vs baseline) but returned to the baseline levels after DSAT. A similar change was observed with the EPC clonogenic potential, but on DSAT the baseline level was incompletely attained.CONCLUSIONS:
In response to SAT, patients with chronic heart failure show enhanced EPC levels and clonogenic potential that is mirrored by increased plasma VEGF and SDF-1 levels. DSAT can interfere with the maintenance of training-acquired VEGF/SDF-1-related EPC levels and clonogenic potential.
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Exercício Físico
/
Células Endoteliais
/
Endotélio
/
Insuficiência Cardíaca
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article