Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum.
Dev Dyn
; 237(1): 51-61, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-18058910
ABSTRACT
Pax4-deficient mice have a severe gastrointestinal endocrine deficiency they lack most pancreatic cells that produce insulin or somatostatin and various duodenal endocrine cell types. Remarkably, Pax4-deficient mice also have an overabundance of ghrelin-expressing cells in the pancreas and duodenum. Detailed analysis of the Pax4 nullizygous pancreas determined that the mutant islets are largely composed of a distinctive endocrine cell type that expresses ghrelin, glucagon, islet amyloid polypeptide (IAPP), and low levels of Pdx1. Lineage-tracing analysis revealed that most of these unique endocrine cells directly arose from Pax4-deficient progenitors. Previous in vitro work reported that Pax4 is a transcriptional repressor of islet amyloid polypeptide (IAPP) and glucagon. In this study, we expanded those results by showing that Pax4 is also a repressor of gherlin. Together, our data further support the notion that Pax4 activity is necessary to establish appropriate patterns of gene expression in endocrine progenitors of the digestive tract.
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Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Proteínas de Homeodomínio
/
Duodeno
/
Fatores de Transcrição Box Pareados
/
Grelina
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article