Revaccination does not improve an observed deficit in antibody responses in Pakistani adults born of a lower birth weight.
Vaccine
; 26(2): 158-65, 2008 Jan 10.
Article
em En
| MEDLINE
| ID: mdl-18068877
ABSTRACT
We have previously shown that the generation of antibodies to a polysaccharide vaccine (Typhim Vi) is compromised in Pakistani adults born of a lower birth weight. To assess whether this represents a true B-cell-dependent deficit, we revaccinated subjects with a second dose of the same vaccine and with a polysaccharide-protein conjugate vaccine to a different polysaccharide antigen (conjugated Haemophilus influenzae type b (Hib) vaccine). Anti-Vi IgG levels remained positively correlated with birth weight (p=0.0284) but no associations were observed between anti-Hib IgG levels and size at birth. These findings indicate that small size at birth results in a poor antibody response to vaccination with a polysaccharide antigen vaccine in adulthood, even following a second dose of the vaccine. No such association was observed in response to a polysaccharide-protein conjugate vaccine indicating an early-life programming effect on the generation of antibodies during a B-cell-dependent immune response.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos Bacterianos
/
Recém-Nascido de Baixo Peso
/
Vacinas Tíficas-Paratíficas
/
Imunização Secundária
/
Vacinas Conjugadas
/
Vacinas Anti-Haemophilus
/
Anticorpos Antibacterianos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article