The sugar conformation governs (6-4) photoproduct formation at the dinucleotide level.
J Am Chem Soc
; 130(1): 30-1, 2008 Jan 09.
Article
em En
| MEDLINE
| ID: mdl-18069836
ABSTRACT
The LNA dinucleotide mimic of TpT whose two-sugar puckers are locked in the C3'-endo conformation selectively produces the corresponding cyclobutane pyrimidine dimer under 254 nm irradiation. In the natural series (TpT) the sugar puckers are in a major C2'-endo sugar conformation and the (6-4) photoproduct is also produced. Consequently, this study demonstrates that the C2'-endo conformation of the sugar pucker is necessary for (6-4) photoproduct formation.
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Base de dados:
MEDLINE
Assunto principal:
Fotoquímica
/
Timidina
/
Carboidratos
/
Fosfatos de Dinucleosídeos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article