Lack of alternative coreceptor use by pediatric HIV-1 R5 isolates for infection of primary cord or adult peripheral blood mononuclear cells.
Arch Virol
; 153(2): 363-6, 2008.
Article
em En
| MEDLINE
| ID: mdl-18074097
ABSTRACT
HIV-1 infection of neonates results in an extended acute period of virus replication, frequent neurological problems and reduced survival compared to adults. In adults, R5 viruses mainly infect CCR5(+) CD4(+) memory T-cells. In neonates, CCR5(+) memory T-cells form a substantially smaller fraction of total lymphocytes. We therefore tested whether alternative coreceptors confer infection of lymphocytes by pediatric isolates. Pediatric HIV-1 R5 isolates failed to replicate in Delta32/Delta32 CCR5 PBMCs or in cord PBMCs treated with a CCR5 inhibitor. These results do not indicate a role for alternative coreceptors and provide support for CCR5 inhibitors in the therapy of HIV-1(+) neonates.
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Base de dados:
MEDLINE
Assunto principal:
Receptores Virais
/
Replicação Viral
/
Leucócitos Mononucleares
/
Infecções por HIV
/
HIV-1
/
Internalização do Vírus
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article