Treatment of hand and foot psoriasis with emphasis on efalizumab.
Skin Therapy Lett
; 12(9): 4-7, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-18087658
ABSTRACT
Hand and foot psoriasis is a chronic and debilitating disease that manifests as plaque-type or pustular-type lesions. Although the palms and soles represent only 2% of the total body surface area, psoriasis of these regions may lead to physical dysfunctions that can greatly impair dexterity, mobility, and the quality of life of affected individuals. Deregulation of T-lymphocyte-mediated immune response is important in the pathophysiology of psoriasis. Efalizumab (Raptiva, Genentech) is an anti-CD11a monoclonal antibody that disrupts the interaction between T cells and antigen-presenting cells, thereby inhibiting various T-cell-mediated immune processes that include activation and trafficking. Recent evidence indicates that efalizumab may be beneficial for patients with hand and foot psoriasis.
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Base de dados:
MEDLINE
Assunto principal:
Psoríase
/
Doenças do Pé
/
Mãos
/
Anticorpos Monoclonais
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article