Elevated levels of prothrombin fragment 1 + 2 indicate high risk of thrombosis.
Clin Appl Thromb Hemost
; 14(3): 279-85, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18160575
ABSTRACT
Prothrombin fragment 1 + 2 (F1 + 2) is considered to be useful for diagnosis of thrombosis. However, the evidence for a diagnosis of thrombosis by F1 + 2 is still not well established. The plasma concentrations of F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex were measured in 694 patients suspected of having thrombosis and then were correlated with thrombosis. Plasma concentrations of F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex were significantly higher in patients with thrombosis, compared with patients without thrombosis. When cutoff values of more than 300 pmol/L for F1 + 2 were used for the diagnosis, more than 50% of the patients were thus found to have thrombosis. The findings showed that F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex have similar diagnostic ability. The plasma concentration of F1 + 2 closely was well correlated with thrombin-antithrombin complex, soluble fibrin, and D-dimer. Finally, F1 + 2 is one of the most useful parameters for the diagnosis of thrombosis.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Trombose
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article