High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae.
Genome Biol
; 9(1): R2, 2008 Jan 03.
Article
em En
| MEDLINE
| ID: mdl-18171483
ABSTRACT
We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Redes Reguladoras de Genes
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article