A low dose adrenocorticotropin test (1 microg ACTH) for the evaluation of adrenal function in children with beta-thalassemia receiving hypertransfusion with suboptimal iron-chelating therapy.
J Pediatr Endocrinol Metab
; 20(11): 1183-8, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-18183789
ABSTRACT
A cross-sectional study of adrenal function was carried out in 48 patients with beta-thalassemia who were receiving hypertransfusion with suboptimal desferoxamine. A low dose adrenocorticotropic hormone (1 microg ACTH) stimulation test was performed using the cut-off criteria of peak cortisol for adrenal sufficiency >18 microg/dl. Adrenal impairment was diagnosed in 22 patients, giving a prevalence of 45.8%. The peak cortisol concentrations in normal and impaired adrenal function groups were 26.22 +/- 2.84 and 14.03 +/- 3.12 microg/dl, respectively, and the mean basal morning cortisol was 8.93 +/- 2.97 and 6.52 +/- 2.45 microg/dl, respectively. There was no significant difference in any clinical characteristic between the patients with impaired adrenal function and those with normal adrenal function.
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Base de dados:
MEDLINE
Assunto principal:
Sideróforos
/
Talassemia beta
/
Insuficiência Adrenal
/
Hormônio Adrenocorticotrópico
/
Desferroxamina
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article