CpG motif-based adjuvant as a replacement for Freund's complete adjuvant in a recombinant LHRH vaccine.
Vaccine
; 26(7): 907-13, 2008 Feb 13.
Article
em En
| MEDLINE
| ID: mdl-18201806
ABSTRACT
This study compared (1) Freund's complete adjuvant and CpG oligodeoxynucleotide (ODN) 2006 in water-in-oil emulsion as adjuvants; and (2) increasing doses of a recombinant ovalbumin-LHRH (ova-LHRH) fusion protein as an antigen for a contraceptive vaccine. Treatment groups (n=8 heifers/group) were one untreated control group; five groups receiving CpG ODN with different doses of ova-LHRH (1.5; 2.3; 3.4; 5.1; and 7.6 mg); and one group receiving 3.4 mg ova-LHRH in Freund's. Heifers were immunized at weeks 0 and 14. All vaccine treatments caused gonadal regression and estrus suppression. CpG ODN is a suitable replacement for Freund's for LHRH immunization.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligodesoxirribonucleotídeos
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Esterilização Reprodutiva
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Vacinas Sintéticas
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Ovalbumina
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Adjuvantes Imunológicos
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Hormônio Liberador de Gonadotropina
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Vacinas Anticoncepcionais
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article