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Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma.
Li, Qiang; Wang, Jian-Ming; Liu, Cong; Xiao, Bao-Lai; Lu, Jin-Xi; Zou, Sheng-Quan.
Afiliação
  • Li Q; Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hepatobiliary Pancreat Dis Int ; 7(1): 70-5, 2008 Feb.
Article em En | MEDLINE | ID: mdl-18234642
ABSTRACT

BACKGROUND:

The abnormal expression of atypical protein kinase C-iota (aPKC-iota) subtype and E-cadherin play important roles in tumor occurrence and progression. This study was designed to investigate the correlation of expression of aPKC-iota and E-cadherin with the clinicopathological characteristics and prognosis of cholangiocarcinoma, and to analyze the molecular mechanisms of invasion and metastasis of the tumor.

METHODS:

EnVision immunohistochemistry was used to detect the expression of aPKC-iota and E-cadherin in 9 specimens of benign bile duct tissues, 35 specimens of cholangiocarcinoma and 6 specimens of metastatic cholangiocarcinoma. The relationship of the expression with clinicopathological characteristics, invasion and prognosis of cholangiocarcinoma was analyzed. A multivariate regression analysis was made of these data by the Cox proportional hazard model.

RESULTS:

The positive expression level of aPKC-iota in cholangiocarcinoma was remarkably higher than that in benign bile duct tissues (68.6% vs. 11.1%, P=0.006), but the expression level of E-cadherin was lower in cholangiocarcinoma than in benign bile duct tissues (37.1% vs. 88.9%, P=0.016). Correlation analysis revealed that the expression of aPKC-iota was positively related to tumor differentiation and invasion, whereas that of E-cadherin was entirely the contrary. Moreover, there was a negative relationship between the expression of aPKC-iota and that of E-cadherin (r=-0.287, P<0.05). Univariate analysis showed that the overall survival rate of the group with a higher expression of aPKC-iota in cholangiocarcinoma was remarkably lower than that of the group with a lower expression (P<0.01); multivariate analysis revealed that the expressions of aPKC-iota and E-cadherin are important prognostic factors for cholangiocarcinoma (P<0.05).

CONCLUSIONS:

The expressions of aPKC-iota and E-cadherin may reflect the differentiation and invasive potential of cholangiocarcinoma. aPKC-iota and E-cadherin may be independent prognostic factors and, when used in combination with clinicopathological characteristics, may increase the accuracy in predicting the prognosis of patients with cholangiocarcinoma. As a polar regulative associated protein, aPKC-iota may play an important role in the invasion and metastasis of cholangiocarcinoma.
Assuntos
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Base de dados: MEDLINE Assunto principal: Neoplasias dos Ductos Biliares / Ductos Biliares Intra-Hepáticos / Proteína Quinase C / Caderinas / Colangiocarcinoma / Isoenzimas Idioma: En Ano de publicação: 2008 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Neoplasias dos Ductos Biliares / Ductos Biliares Intra-Hepáticos / Proteína Quinase C / Caderinas / Colangiocarcinoma / Isoenzimas Idioma: En Ano de publicação: 2008 Tipo de documento: Article