Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.
Bioorg Med Chem Lett
; 18(5): 1668-73, 2008 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-18243701
ABSTRACT
A series of tri- and tetra-substituted naphthalene diimides have been designed and synthesized. Several compounds show exceptional affinity for telomeric G-quadruplex DNA in classical and competition FRET assays and SPR studies. They inhibit telomerase in the TRAP assay, and show potent senescence-based short-term anti-proliferative effects on MCF7 and A549 cancer cell lines, and localize in the nucleus and particularly the nucleolus of MCF7 cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenantrolinas
/
Quadruplex G
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article