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Predictors of all-cause mortality in chronic Chagas' heart disease in the current era of heart failure therapy.
Theodoropoulos, Tatiana A D; Bestetti, Reinaldo B; Otaviano, Ana Paula; Cordeiro, José A; Rodrigues, Vanessa C; Silva, Adriana C.
Afiliação
  • Theodoropoulos TA; Department of Cardiology and Cardiovascular Surgery, Hospital de Base, Faculty of Medicine of São José do Rio Preto, São José do Rio Preto, Brazil.
Int J Cardiol ; 128(1): 22-9, 2008 Aug 01.
Article em En | MEDLINE | ID: mdl-18258318
BACKGROUND AND AIMS: We sought to identify predictors of all-cause mortality for Chagas' disease patients with chronic systolic heart failure because they are virtually lacking in the current era of heart failure therapy. METHODS AND RESULTS: This study focus on 127 patients with the diagnosis of chronic systolic heart failure secondary to Chagas' cardiomyopathy. Mean follow up was 25+/-19 months. Sixty-three (50%) patients died during the study period. Cox regression analysis showed lack of B-blocking agent use (p=0.002, hazard ratio=0.30, 95% Confidence Interval 0.14 to 0.64), serum sodium levels (p=0.01, hazard ratio=0.93, 95% Confidence Interval 0.87 to 0.98), left ventricular ejection fraction (p=0.02, hazard ratio=0.96, 95% Confidence Interval 0.93 to 0.99), digoxin treatment (p=0.04, hazard ratio=8.47, 95% Confidence Interval 1.13 to 62.52) and New York Heart Association Class IV on admission (p=0.034, hazard ratio=1.92, 95% Confidence Interval 1.02 to 3.51) independent predictors of all-cause mortality. CONCLUSION: Lack of B-blocking agent use, serum sodium levels, left ventricular ejection fraction, digoxin treatment and New York Heart Association Class IV are independent predictors of all-cause mortality for patients with chronic heart failure secondary to Chagas' cardiomyopathy in the current era of heart failure therapy.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiomiopatia Chagásica / Insuficiência Cardíaca Sistólica Idioma: En Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiomiopatia Chagásica / Insuficiência Cardíaca Sistólica Idioma: En Ano de publicação: 2008 Tipo de documento: Article