[Cross-reactivity to honeybee and wasp venom]. / Kreuzreaktivität auf Bienen- und Wespengift.
Hautarzt
; 59(3): 194-9, 2008 Mar.
Article
em De
| MEDLINE
| ID: mdl-18265954
ABSTRACT
About 30-40% of patients with insect venom allergy have IgE antibodies reacting with both honeybee and Vespula venom. Apart from true double sensitization, IgE against cross-reactive carbohydrate determinants (CCDs, alpha1,3-fucosylated N-glycans) with low clinical relevance is the most frequent and often only cause for the multiple reactivity. Venom hyaluronidases have been identified as the most important allergens displaying CCDs, whereas cross-reactions through the hyaluronidases' peptide backbones are less common. If IgE binding to CCDs is disregarded, Vespula venom hyaluronidase is only a minor allergen. In-vitro tests using fucosylated plant glycoproteins (e.g. assessment of specific IgE antibodies by CAP-FEiA to bromelain) are helpful in identifying sera containing CCD-specific IgE, although a positive result (occurring in 70-80% of all double-positive sera) does not reliably exclude true double-sensitization. Reciprocal in-vitro inhibition including non-venom inhibitor proteins rich in CCDs is the method of choice to discriminate between double-sensitization and cross-reactivity. Future in-vitro diagnosis will be markedly improved when recombinant allergens lacking CCDs become commercially available.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Venenos de Vespas
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Vespas
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Venenos de Abelha
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Abelhas
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Hipersensibilidade Imediata
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Mordeduras e Picadas de Insetos
Idioma:
De
Ano de publicação:
2008
Tipo de documento:
Article