[Transient receptor potential, TRP channels: a new family of channels broadly expressed]. / Les canaux TRP (transient receptor potential): une nouvelle famille de canaux à expression variée.
Med Sci (Paris)
; 24(2): 163-8, 2008 Feb.
Article
em Fr
| MEDLINE
| ID: mdl-18272078
ABSTRACT
Transient receptor potential, TRP channels are a new superfamily of functionally versatile non-selective cation channels present from yeast to mammals. On the basis of their structural homology, TRP channels are subdivided in 7 groups TRPC 1-7 Canonical, TRPV 1-6 Vanilloid, TRPM 1-8 Melastatin, TRPP 1-3 Polycystin, TRPML Mucolipin, TRPA Ankyrin and TRPN (NO mechanotransducer potential C), the latter not expressed in mammals. Their cloning and heterologous expression allowed to demonstrating that these channels are generally weakly voltage-dependent. They are activated by various ligands involving a signal transduction cascade as well as directly by multiple compounds, heat and pH. TRP channels are found in a broad range of cell types. TRP channels are essential in allowing animals to sense the outside world and cells to sense their local environment. Following mutations or anomalous behaviour, these channels have a major role in several human diseases.
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Base de dados:
MEDLINE
Assunto principal:
Canais de Cátion TRPC
Idioma:
Fr
Ano de publicação:
2008
Tipo de documento:
Article