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Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation.
López-Avilés, Sandra; Lambea, Eva; Moldón, Alberto; Grande, Maribel; Fajardo, Alba; Rodríguez-Gabriel, Miguel A; Hidalgo, Elena; Aligue, Rosa.
Afiliação
  • López-Avilés S; Departament de Biologia Cellular, Universitat de Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Catalunya, Spain.
Mol Biol Cell ; 19(4): 1670-9, 2008 Apr.
Article em En | MEDLINE | ID: mdl-18272791
Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. The Schizosaccharomyces pombe SAPK Sty1/Spc1 orchestrates general changes in gene expression in response to diverse forms of cytotoxic stress. Here we show that Sty1/Spc1 is bound to its target, the Srk1 kinase, when the signaling pathway is inactive. In response to stress, Sty1/Spc1 phosphorylates Srk1 at threonine 463 of the regulatory domain, inducing both activation of Srk1 kinase, which negatively regulates cell cycle progression by inhibiting Cdc25, and dissociation of Srk1 from the SAPK, which leads to Srk1 degradation by the proteasome.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Schizosaccharomyces / Proteínas Quinases Ativadas por Mitógeno / Proteínas de Schizosaccharomyces pombe Idioma: En Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Schizosaccharomyces / Proteínas Quinases Ativadas por Mitógeno / Proteínas de Schizosaccharomyces pombe Idioma: En Ano de publicação: 2008 Tipo de documento: Article