C-reactive protein (CRP) increases VEGF-A expression in monocytic cells via a PI3-kinase and ERK 1/2 signaling dependent pathway.
Atherosclerosis
; 200(2): 286-93, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18280482
ABSTRACT
C-reactive protein (CRP) is an independent predictor of atherosclerosis and its complications. Monocytes/macrophages are implicated in this complex disease which is, among other mechanisms, characterised by angiogenesis. The aim of this study was to analyse whether CRP plays a role in VEGF-A regulation by monocytic cells. Our findings show that CRP up-regulates VEGF-A mRNA expression and protein excretion in THP-1 cells in a concentration- and time-dependent manner. Furthermore, we studied the signaling pathway underlying this effect. CRP increases VEGF-A expression via a PI3-kinase and an extracellular-signal-regulated kinase (ERK) 1/2 dependent pathway. Our results suggest that CRP could play a role in the angiogenesis process via immune cells such as monocytes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
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Monócitos
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Fosfatidilinositol 3-Quinases
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Proteína Quinase 1 Ativada por Mitógeno
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Fator A de Crescimento do Endotélio Vascular
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Proteína Quinase 3 Ativada por Mitógeno
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article