Aromatase and interleukin-10 genetic variants interactively modulate Alzheimer's disease risk.
J Neural Transm (Vienna)
; 115(6): 863-7, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18299793
ABSTRACT
A chronic inflammatory process with activation of microglial cells contribute to the neurodegeneration associated with Alzheimer's disease (AD). Estrogen could protect the brain from neurodegeneration by augmenting the secretion of the anti-inflammatory interleukin (IL)-10 from microglial cells. In a case-control study in 231 AD patients and 194 healthy controls, we examined whether the combined effects between the genes coding for aromatase (a critical enzyme in the peripheral synthesis of estrogens) and IL-10 might be responsible for susceptibility to AD. Subjects carrying both the aromatase (5 -UTR) GG and the IL-10 (-1082) GG genotypes had a six times lower risk of developing AD than subjects without these risk genotypes (OR = 0.17, 95% CI = 0.04-0.77, P = 0.02).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Aromatase
/
Interleucina-10
/
Predisposição Genética para Doença
/
Estrogênios
/
Doença de Alzheimer
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article