Topology and function of CcmD in cytochrome c maturation.
J Bacteriol
; 190(10): 3489-93, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18326572
ABSTRACT
The system I cytochrome c biogenesis pathway requires CcmD, a small polypeptide of 69 residues in Escherichia coli. Here it is shown that CcmD is a component of the CcmABC ATP-binding cassette transporter complex. CcmD is not necessary for the CcmC-dependent transfer of heme to CcmE in the periplasm or for interaction of CcmE with CcmABC. CcmD is absolutely required for the release of holo-CcmE from the CcmABCD complex. Evidence is presented that the topology of CcmD in the cytoplasmic membrane is the N terminus outside and the C terminus inside with one transmembrane domain.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
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Proteínas de Escherichia coli
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Citocromos c
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Escherichia coli
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Proteínas de Membrana
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article