Synthesis and in vivo studies of carbohydrate-based vaccines against group A streptococcus.
Biopolymers
; 90(5): 611-6, 2008.
Article
em En
| MEDLINE
| ID: mdl-18381625
ABSTRACT
Carbohydrates, as carriers, providing numerous attachment points for the conjugation of peptide antigens and their optimal orientation for the recognition by cells of the immune system, reducing degradation of the attached peptide antigens and many other advantages make carbohydrate-based vaccine highly promising approach. Multiple copies of a single group A streptococcal (GAS) M protein derived specific peptide antigens (J8 or J14) were coupled onto carbohydrate cores (D-glucose and D-galactose) linked to lipophilic amino acids to produce a self-adjuvanting liposaccharide vaccine against GAS strains. In vivo experiments showed high serum IgG antibody titers against each of the incorporated peptide epitopes, J8 or J14.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Infecções Estreptocócicas
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Streptococcus pyogenes
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Sistemas de Liberação de Medicamentos
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Vacinas Estreptocócicas
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Galactose
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Glucose
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Antígenos de Bactérias
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article