Reduced maximal oxygen consumption and overproduction of proinflammatory cytokines in athletes.
Neuroimmunomodulation
; 14(6): 304-9, 2007.
Article
em En
| MEDLINE
| ID: mdl-18382117
ABSTRACT
OBJECTIVE:
It was the aim of this study to evaluate whether chronic pain in athletes is related to performance, measured by the maximum oxygen consumption and production of hormones and cytokines.METHODS:
Fifty-five athletes with a mean age of 31.9 +/- 4.2 years engaged in regular competition and showing no symptoms of acute inflammation, particularly fever, were studied. They were divided into 2 subgroups according to the occurrence of pain. Plasma concentrations of adrenaline, noradrenaline, cortisol, prolactin, growth hormone and dopamine were measured by radioimmunoassay, and the production of the cytokines interleukin (IL)-1, IL-2, IL-4, IL-6, tumor necrosis factor-alpha, interferon-alpha and prostaglandin E(2) by whole-blood culture. Maximal oxygen consumption was determined during an incremental treadmill test.RESULTS:
There was no change in the concentration of stress hormones, but the athletes with chronic pain showed a reduction in maximum oxygen consumption (22%) and total consumption at the anaerobic threshold (25%), as well as increased cytokine production. Increases of 2.7-, 8.1-, 1.7- and 3.7-fold were observed for IL-1, IL-2, tumor necrosis factor-alpha and interferon-alpha, respectively.CONCLUSIONS:
Our data show that athletes with chronic pain have enhanced production of proinflammatory cytokines and lipid mediators and reduced performance in the ergospirometric test.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
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Dor
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Esportes
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Citocinas
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Hormônios
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article