Use of real-time PCR to detect human papillomavirus-16 viral loads in vaginal and urine self-sampled specimens.
Clin Microbiol Infect
; 14(6): 619-21, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18384392
ABSTRACT
Increasing the accuracy of self-sampling methods to detect oncogenic human papillomavirus (HPV) infection would contribute to the wider application of these approaches. In this study, 120 women were tested for HPV-16 by conventional and quantitative real-time PCR (QRT-PCR) in cervical and self-sampled vaginal and urine specimens. QRT-PCR had a higher detection rate, and the HPV viral load in all three sampling sites correlated with the severity of disease, as determined by histology. The vaginal and urine viral loads correlated with HPV-16 positivity according to both conventional and QRT-PCR, and were proportional to the cervical viral load.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Urina
/
Vagina
/
Neoplasias do Colo do Útero
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Infecções por Papillomavirus
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Papillomavirus Humano 16
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article