A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population.
Mol Genet Metab
; 94(3): 386-8, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18400535
ABSTRACT
Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1D), making this gene an interesting T1D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1D could not be demonstrated.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mutação de Sentido Incorreto
/
Proteínas de Transporte de Cátions
/
Diabetes Mellitus Tipo 1
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article