Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine.
Bioorg Med Chem
; 16(10): 5653-64, 2008 May 15.
Article
em En
| MEDLINE
| ID: mdl-18417347
ABSTRACT
A series of 7,8- and 8,9-fused pyrimidinone, aminopyrimidine and pyridone derivatives of 8-carboxamidocyclazocine (8-CAC) have been prepared and evaluated in opioid receptor binding assays. Targets were designed to corroborate a pharmacophore hypothesis regarding the bioactive conformation of the carboxamide of 8-CAC. In addition to the results from this study strongly supporting this pharmacophore hypothesis, a number of novel compounds with high affinity to opioid receptors have been identified.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Azocinas
/
Receptores Opioides
/
Ciclazocina
/
Antagonistas de Entorpecentes
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article