Basolateral entry and release of New and Old World arenaviruses from human airway epithelia.
J Virol
; 82(12): 6034-8, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18417570
ABSTRACT
Transmission of arenaviruses from rodent hosts to humans is generally thought to occur through inhalation or ingestion of dust or droplets containing viral particles. Here we demonstrate that two identified arenavirus receptors, alpha-dystroglycan (alpha-DG) and transferrin receptor 1 (TfR1), are expressed in polarized human airway epithelia. Lymphocytic choriomeningitis virus strains with high or low alpha-DG affinity and Junin virus, which binds TfR1, efficiently infected polarized epithelia only when applied to the basolateral surface or when injury compromised tight junction integrity. Viral egress from infected epithelia exhibited basolateral polarity. This study demonstrates that respiratory entry of arenaviruses occurs via basolateral receptors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema Respiratório
/
Arenavirus do Velho Mundo
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Arenavirus do Novo Mundo
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Células Epiteliais
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article