Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.
J Med Chem
; 51(10): 2879-82, 2008 May 22.
Article
em En
| MEDLINE
| ID: mdl-18426196
ABSTRACT
Tumorigenesis is a multistep process in which oncogenes play a key role in tumor formation, growth, and maintenance. MET was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. Deregulated signaling in the c-Met pathway has been observed in multiple tumor types. Herein we report the discovery of potent and selective triazolopyridazine small molecules that inhibit c-Met activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridazinas
/
Triazóis
/
Proteínas Proto-Oncogênicas c-met
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article