Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates.
Curr Protoc Nucleic Acid Chem
; Chapter 15: Unit 15.1, 2006 Jul.
Article
em En
| MEDLINE
| ID: mdl-18428952
Diphenyl phosphite and bis(N,N-diisopropylamino)chlorophosphine are used as phosphitylating reagents to generate H-phosphonate monoesters. These H-phosphonate intermediates are subsequently oxidized with iodine to generate the 5'-nucleoside amino acid phosphoramidates.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Fosfóricos
/
Organofosfonatos
/
Amidas
/
Aminoácidos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article