Random monoallelic expression: making a choice.
Trends Genet
; 24(6): 257-9, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18450315
ABSTRACT
Monoallelic gene expression exposes an organism to the risks associated with the unmasking of recessive mutations. A recent study by Gimelbrant and colleagues, supported by results from two methodologically different studies, demonstrated that random monoallelic expression is surprisingly widespread among autosomal genes. This raises important questions about why, when and how cells choose and tolerate monoallelism and whether functional hemizygosity might provide an unappreciated advantage.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Impressão Genômica
/
Desequilíbrio Alélico
/
Padrões de Herança
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article