Library of biphenyl privileged substructures using a safety-catch linker approach.
J Comb Chem
; 10(4): 557-66, 2008.
Article
em En
| MEDLINE
| ID: mdl-18462009
ABSTRACT
A biphenyl privileged structure library containing three attachment points were synthesized using a catechol-based safety-catch linker strategy. The method requires the attachment of a bromo-acid to the linker, followed by a Pd-catalyzed Suzuki cross-coupling reaction. Further derivatization, activation of the linker with strong acid and aminolysis afforded the respective products in high purity and good overall yield. To show the versatility of the synthesis, a 199-member library was generated. The library samples both conformational and chemical diversity about a well-known privileged substructure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Bifenilo
/
Reagentes de Ligações Cruzadas
/
Técnicas de Química Combinatória
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article