Lipoxins: update and impact of endogenous pro-resolution lipid mediators.
Rev Physiol Biochem Pharmacol
; 160: 47-70, 2008.
Article
em En
| MEDLINE
| ID: mdl-18481030
ABSTRACT
Lipoxins (LXs) are endogenously produced eicosanoids that are typically generated by transcellular biosynthesis. These trihydroxytetraene-containing lipid mediators and their stable synthetic analogues possess a wide spectrum of anti-inflammatory and pro-resolution bioactions both in vitro and in vivo. More recently, LXs have emerged as potential anti-fibrotic mediators that may influence pro-fibrotic cytokines and matrix-associated gene expression in response to platelet-derived growth factor (PDGF). Here we review the biosynthesis, metabolism and bioactions of LXs and LX analogues and their therapeutic potential.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lipoxinas
/
Metabolismo dos Lipídeos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article