Effects of undernutrition on glutamatergic parameters in the cerebral cortex of young rats.
Physiol Behav
; 94(4): 580-5, 2008 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-18485424
ABSTRACT
Perinatal undernutrition impairs maturational events in the development of the brain, resulting in a variety of brain dysfunctions, which affect cognitive functions. This study investigated the effects of pre- and post-natal undernutrition (diet 8% protein; control group 25% protein) on some glutamatergic and behavioral parameters of 21-day-old rats. In the cerebral cortex, undernutrition reduced the Na-independent [(3)H]Glutamate binding in cellular membranes and [(3)H]Glutamate vesicular uptake, without affecting the [(3)H]Glutamate uptake by slices preparation. Behavioral parameters were affected, showing a strong amnesic effect both in the short- and long-term memory of inhibitory avoidance tasks, and a significant reduction in the number of crossings in an open field. The effects of perinatal undernutrition in 21-day-old rats, which alter some glutamatergic parameters may be related to the impairment of memory in certain behavioral tasks.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aprendizagem da Esquiva
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Córtex Cerebral
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Ácido Glutâmico
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Desnutrição
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Comportamento Exploratório
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article