Diacid linkers that promote parallel beta-sheet secondary structure in water.
J Am Chem Soc
; 130(25): 7839-41, 2008 Jun 25.
Article
em En
| MEDLINE
| ID: mdl-18507461
ABSTRACT
We report the development of diacid units that promote formation of a two-stranded parallel beta-sheet secondary structure between peptide segments attached via their N-termini. These linker units are formed by attaching glycine to one carboxyl group of cis-1,2-cyclohexanedicarboxylic acid (CHDA). Parallel sheet formation in water is observed when l-residue strands are attached to the CHDA-Gly unit with either of the two absolute configurations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos
/
Água
/
Estrutura Secundária de Proteína
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article