HIV Gag-specific immune responses predict the rate of CD4 decline.
AIDS
; 22(10): 1222-4, 2008 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-18525269
ABSTRACT
In the present study, we assessed whether Gag-specific interferon (IFN)-gamma secreting responses correlate with the rate of disease progression as defined by the annual rate of CD4 decline. Although neither the breadth nor the magnitude of the proteome-wide HIV-specific IFN-gamma response correlated with viral load or rate of CD4 decline, the preferential targeting of Gag is associated with slower annual CD4 T cell decline.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
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Genes gag
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Infecções por HIV
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HIV-1
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Interferon gama
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Linfopenia
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article