Discovery of potent, orally active benzimidazole glucagon receptor antagonists.
Bioorg Med Chem Lett
; 18(13): 3701-5, 2008 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-18539028
ABSTRACT
The discovery and optimization of potent and selective aminobenzimidazole glucagon receptor antagonists are described. One compound possessing moderate pharmacokinetic properties in multiple preclinical species was orally efficacious at inhibiting glucagon-mediated glucose excursion in transgenic mice expressing the human glucagon receptor, and in rhesus monkeys. The compound also significantly lowered glucose levels in a murine model of diabetes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzimidazóis
/
Receptores de Glucagon
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article