Rhenium-catalyzed synthesis of multisubstituted aromatic compounds via C-C single-bond cleavage.
Org Lett
; 10(14): 3133-5, 2008 Jul 17.
Article
em En
| MEDLINE
| ID: mdl-18563904
ABSTRACT
A reaction between a beta-keto ester and an acetylene in the presence of a rhenium complex, [ReBr(CO)3(thf)]2, as a catalyst, provided a 2-pyranone derivative in excellent yield via retro-aldol reaction (C-C single bond cleavage). By adding an acetylene-bearing ester group(s) after the formation of 2-pyranones, an aromatization reaction proceeded and multisubstituted aromatic compounds were obtained in good to excellent yields.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Pironas
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Rênio
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Alcinos
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Hidrocarbonetos Aromáticos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article