Factors associated with the occurrence of epistaxis in natural canine leishmaniasis (Leishmania infantum).
J Vet Intern Med
; 22(4): 866-72, 2008.
Article
em En
| MEDLINE
| ID: mdl-18564224
ABSTRACT
BACKGROUND:
Canine leishmaniasis (CanL) is a common cause of epistaxis in dogs residing in endemic areas. The pathogenesis of CanL-associated epistaxis has not been fully explored because of the limited number of cases reported so far.HYPOTHESIS:
Epistaxis in CanL could be attributed to more than 1 pathomechanism such as hemostatic dysfunction, biochemical abnormalities, chronic rhinitis, and coinfections occurring in various combinations. ANIMALS Fifty-one dogs with natural CanL.METHODS:
The allocation of 51 dogs in this cross-sectional study was based on the presence (n = 24) or absence (n = 27) of epistaxis. The potential associations among epistaxis and concurrent infections (Ehrlichia canis, Bartonella spp., and Aspergillus spp.), biochemical and hemostatic abnormalities, and nasal histopathology were investigated.RESULTS:
Hypergammaglobulinemia (P= .044), increased serum viscosity (P= .038), decreased platelet aggregation response to collagen (P= .042), and nasal mucosa ulceration (P= .039) were more common in the dogs with epistaxis than in those without epistaxis. The other significant differences between the 2 groups involved total serum protein (P= .029) and gamma-globulin (P= .013) concentrations, which were higher, and the percentage platelet aggregation to collagen, which was lower (P= .012) in the epistaxis dogs. CLINICAL IMPORTANCE CanL-associated epistaxis appears to be the result of multiple and variable pathogenetic factors such as thrombocytopathy, hyperglobulinemia-induced serum hyperviscosity, and nasal mucosa ulceration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Epistaxe
/
Doenças do Cão
/
Leishmaniose Visceral
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article