Peripheral neuropathy as the sole initial finding in three children with infantile metachromatic leukodystrophy.
Eur J Paediatr Neurol
; 13(3): 257-60, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-18571943
ABSTRACT
Metachromatic leukodystrophy (MLD) is a progressive white matter disease caused by arylsulfatase A deficiency. Demyelination in the nervous system is detected by cerebral magnetic resonance imaging (MRI) and neurophysiological studies. We present three children with infantile MLD, who had difficulties in standing and walking with absent reflexes. Protein levels in cerebral spinal fluid (CSF) were elevated and nerve conduction studies revealed slowing down of motor nerve conduction velocity. Initial cerebral MRIs showed no white matter changes. Consecutively, all three children developed clinical symptoms of neurodegenerative disease. Follow-up MRI and arylsulfatase A testing led to diagnosis of MLD. We conclude, that in young children who present with an acute/subacute demyelinating polyneuropathy, MLD is a differential diagnosis.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Desmielinizantes
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Doenças do Sistema Nervoso Periférico
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Debilidade Muscular
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Leucodistrofia Metacromática
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Condução Nervosa
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article