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Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP.
Comment, A; Rentsch, J; Kurdzesau, F; Jannin, S; Uffmann, K; van Heeswijk, R B; Hautle, P; Konter, J A; van den Brandt, B; van der Klink, J J.
Afiliação
  • Comment A; Institut de Physique des Nanostructures, Ecole Polytechnique Fédérale de Lausanne, Station 3, CH-1015 Lausanne, Switzerland. arnaud.comment@epfl.ch
J Magn Reson ; 194(1): 152-5, 2008 Sep.
Article em En | MEDLINE | ID: mdl-18595751
ABSTRACT
New low-temperature inserts compatible with an existing hyperpolarizer were developed to dynamically polarize nuclei in large samples. The performance of the system was tested on 8 ml glassy frozen solutions containing 13C-labeled molecules and doped with nitroxyl free radicals. The obtained 13C low-temperature polarization was comparable to the one measured on 20 times smaller sample volume with only 3-4 times higher microwave power. By using a dissolution insert that fits to the new design, it was possible to obtain about 120 ml of room-temperature hyperpolarized solution. The polarization as well as the molecule concentration was comparable to the values obtained in standard size hyperpolarized samples. Such large samples are interesting for future studies on larger animals and possibly for potential clinical applications.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Soluções / Isótopos de Carbono / Espectroscopia de Ressonância Magnética / Fracionamento Químico / Marcação por Isótopo Idioma: En Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Soluções / Isótopos de Carbono / Espectroscopia de Ressonância Magnética / Fracionamento Químico / Marcação por Isótopo Idioma: En Ano de publicação: 2008 Tipo de documento: Article