New opportunities with the Duff reaction.
J Org Chem
; 73(15): 5989-92, 2008 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-18597528
ABSTRACT
The Duff reaction (HMTA, AcOH or TFA) was studied on substituted [6 + 5] heterocyclic compounds. This reaction provides a useful route to aldehydes for compounds bearing sensitive amide functions. It gives also access to tricyclic lactams of potential biological interest. The formation of an aminomethyl intermediate in the Duff reaction mechanism is unequivocally demonstrated.
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1
Base de dados:
MEDLINE
Assunto principal:
Compostos Heterocíclicos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article