Fatal myelotoxicity after azathioprine treatment.
Nucleosides Nucleotides Nucleic Acids
; 27(6): 661-5, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18600523
ABSTRACT
Azathioprine and 6-mercaptopurine have been used for many years in the treatment of inflammatory bowel disease. Approximately 0.3% of the population are homozygous for variant alleles associated with extremely low thiopurine S-methyltransferase enzyme activity. We describe the case of a young patient with ulcerative colitis, homozygous for TPMT*3A alleles, who suffered fatal azathioprine-induced myelotoxicity after standard dosing with azathioprine. Screening for decreased activity of TPMT in patients prior to azathioprine treatment is advised to minimize the risk of drug-induced toxicity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Azatioprina
/
Medula Óssea
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article