Small RNAs and cancerogenesis.
Biochemistry (Mosc)
; 73(5): 514-27, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18605976
ABSTRACT
Disturbances of microRNA generation and functioning as inhibitors of gene expression at the translational level are considered as specific and diagnostic features of cancer. This review also highlights the role of short interfering RNA (siRNA) in modified epigenomic chromatin structure, which may cause cancer transformation. Future directions of cancer epigenomics are considered in the light of the involvement of siRNA in epigenomic modification of chromatin.
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Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
/
RNA Interferente Pequeno
/
Neoplasias
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article