Granulomatous rosacea and Crohn's disease in a patient homozygous for the Crohn-associated NOD2/CARD15 polymorphism R702W.
Exp Dermatol
; 17(12): 1057-8, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-18616576
ABSTRACT
NOD2/CARD15 belongs to the N-terminal caspase recruitment domain family of proteins involved in regulating NF-kB activation in response to inflammatory stimuli transduced through Toll-like receptors. Mutations and polymorphisms in the NOD2/CARD15 gene reduce antibacterial responses and are associated with granulomatous inflammatory conditions such as Blau syndrome and early-onset sarcoidosis. The polymorphism R702W (arginine to tryptophan) is strongly associated with susceptibility to Crohn's disease in Caucasian populations. Skin abnormalities (other than cutaneous manifestations of Crohn's disease) have not been previously associated with R702W. We report on a female patient homozygous for R702W who developed granulomatous rosacea at the age of 12 years old. From the occurrence in the context of Crohn associated with R702W, we speculate that granulomatous rosacea may be an entity distinct from other forms of rosacea, which are associated with increased production of antibacterial proteins such as cathelicidin.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doença de Crohn
/
Rosácea
/
Polimorfismo de Nucleotídeo Único
/
Proteína Adaptadora de Sinalização NOD2
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article