[Association between raised IL-8 serum levels and resistance to combined peg-interferon plus ribavirin therapy in HCV+ active chronic hepatitis]. / associazione tra elevati livelli sierici di IL-8 e resisitenza alla terapia combinata con PEG-interferon + ribavirina nell'epatite cronica attiva HCV+.
Infez Med
; 16(2): 80-5, 2008 Jun.
Article
em It
| MEDLINE
| ID: mdl-18622147
ABSTRACT
IL-8 serum levels were measured in a group of 44 patients affected with Chronic Active Hepatitis (CAH) HCV+ at the beginning and end of peg-interferon plus ribavirin combined therapy. IL-8 levels were compared with those measured in a group of healthy controls. The patients were treated for 12 months, and then followed up for 6 months after the end of the therapy. IL-8 serum levels were detected by ELISA at the beginning and end of the therapy, and then at the end of the follow-up. IL-8 serum levels were significantly more elevated (p<0.01) in CAH HCV+ patients than in the healthy controls. Furthermore, IL-8 serum levels in those patients who subsequently showed a sustained virological response to the therapy, declined on treatment and maintained lower levels than in those who did not respond to therapy. Serum IL-8 can be considered and proposed as a non-invasive and predictive marker of response to combined PEG IFN alpha2b + Ribavirin in CAH HCV +.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Ribavirina
/
Interleucina-8
/
Interferon-alfa
/
Hepatite C Crônica
Idioma:
It
Ano de publicação:
2008
Tipo de documento:
Article