No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry.
Psychiatr Genet
; 18(4): 208-10, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18628684
ABSTRACT
Single nucleotide polymorphisms (SNPs) in the trace amine associated receptor trace amine associated receptor 6 gene and 3' flanking region have been shown to be associated with schizophrenia. To replicate these findings, we conducted a family-based association study with the five most significant SNPs in our sample of 79 sib-pair families (56/79 sib-pair families showed linkage to 6q23) and 125 triads. No evidence for association was obtained between these SNPs and schizophrenia in our sample, even when limited to the 56 linked families (P>0.2). We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our family samples.
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Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Proteínas Nucleares
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Proteínas de Ciclo Celular
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Predisposição Genética para Doença
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Receptores Acoplados a Proteínas G
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População Branca
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Ligação Genética
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article