Severe everolimus-associated pneumonitis in a renal transplant recipient.
Nephrol Dial Transplant
; 23(10): 3353-5, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18658177
ABSTRACT
Inhibitors of mTOR (mammalian target of rapamycin) are immunosuppressants with less nephrotoxic potential than calcineurin inhibitors and antiproliferative effects, which are advantageous in the case of malignancy. However, a series of adverse events has been reported with the first-generation mTOR inhibitor sirolimus that includes hypersensitivity-like interstitial pneumonitis. To our knowledge, only one case of a pneumonitis associated with everolimus in a heart transplant patient has been reported, and it was related to elevated trough blood levels. We report herein the first case of a kidney graft recipient who developed everolimus-associated pneumonitis with normal trough blood levels that was completely reversed after drug withdrawal.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Doenças Pulmonares Intersticiais
/
Sirolimo
/
Imunossupressores
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article