On sensitivity amplification in intracellular signaling cascades.
Phys Biol
; 5(3): 036004, 2008 Jul 29.
Article
em En
| MEDLINE
| ID: mdl-18663279
ABSTRACT
Sensitivity amplification has long been regarded as a virtually universal property of signal transduction cascades, yet a comprehensive parameter analysis remains a challenge even for relatively simple networks. We use a fast and accurate method to compute properties of multilevel cascades of activation-inactivation cycles and show that the monocyclic cascades amplify sensitivity only under specific conditions. In particular, it is found that efficient sensitivity amplification in a cascade, relative to the sensitivities of individual cycles, requires asymmetry in saturation of converter enzymes, with inhibitors much more saturated than activators.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Algoritmos
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Simulação por Computador
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Transdução de Sinais
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Espaço Intracelular
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Modelos Biológicos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article