Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(17): 4817-22, 2008 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-18682322
ABSTRACT
A series of piperazinebenzylalcohols were prepared and studied to compare with their ketone and amine analogs as MC4R antagonists. Several benzylalcohols such as 14a and 14g displayed low nanomolar binding affinities (K(i)<10 nM), and high selectivities over other melanocortin receptor subtypes.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Álcoois Benzílicos
/
Receptor Tipo 4 de Melanocortina
/
Aminas
/
Cetonas
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article